MSCs from postmenopausal women with osteoporosis were found to have less sensitivity to insulin-like growth factor and a weaker ability to differentiate into osteoblasts, compared to normal controls, while postmenopausal women with osteoporosis were found to express a differential responsiveness of MSCs to leptin, resulting to a variability of the MSC osteogenic potential [104]. Here, LEP is linked to osteoporosis.