STAT3 and gastric cancer: While this study did not indicate the exact communicators between GC cells and CAFs, Wu X et al. [41] showed that GC-derived CAFs secrete significant quantities of IL-6, which can induce EMT phenomenon and increase migration of GC cells through activation of Janus kinase 2/signal transducers and activators of transcription (JAK2/STAT3) pathway in GC cells.