Although several secretory proteins such as macrophage colony-stimulating factor (M-CSF) [108], interleukin 33 (IL-33) [109], CCL2, and interleukin 6 (IL-6) [110] have been suggested as stimulators derived from CAFs for M2 macrophage in esophageal and pancreatic cancers, it has never been reported in GC and should be discovered to be applied for clinical setting in the future. The gene discussed is IL6; the disease is familial pancreatic carcinoma.