Therefore, it is not surprising that the sensitivity of these two ANAs for diagnosis of AMA-negative PBC was rather low, which is also in line with a previous meta-analysis in that the sensitivities ranged from 26% to 29% for anti-gp210 and from 21% to 25% for anti-sp100 for the diagnosis of PBC patients (AMA positive or negative) [18]. The gene discussed is SP100; the disease is primary biliary cholangitis.