The mechanisms of how Hp infection could induce colon polyps and carcinomas are still unclear, and research has shown that gastrin and cyclooxygenase-2 (COX-2) were involved; gastrin can regulate gastric acid secretion, promote the proliferation of gastric mucosa, and promote the proliferation and metastasis of gastric tumor cells [19, 20]. Here, PTGS2 is linked to intestinal disorder.