IL1RL1 and neoplasm: Alternatively, patients with tumor budding, possibly a poor prognosis factor, were associated with abundant desmoplasia (Supplementary Figure 3B, Chi-square for trends, p = 0.02) and decreased stromal ST2 [Figure 4C, Mean pos/area ± SD (AU): 0.26 ± 0.091 vs. 0.415 ± 0.204 without TB, p = 0.031].