But also, IL-33 from stromal fibroblasts can promote macrophage polarization to an M2 profile, secretion of MMP-9 and metastasis, as seen in an pancreatic adenocarcinoma model (75), and indirectly, IL-33 can also induce chemokine secretion by the tumor, recruiting M2 type macrophages (38) and contributing to greater desmoplasia. Here, MMP9 is linked to neoplasm.