SPARC and neoplasm: Vegf mRNA expression was higher in Sparc-deficient PMN-MDSC and M-MDSC (Figure 5A), as it was the amount of VEGF in the serum of Sparc−/− mice injected with Sparc-deficient rather than WT MDSC (Figure 5B), suggesting that the lack of SPARC in MDSC may favor tumor vascularization.