Confocal microscopy analysis revealed that SPARC-deficient MDSC showed a significantly lower amount of p50 but not of p65 into the nucleus (Figure 3G and Supplementary Figure 3) than SPARC-competent MDSC, at baseline or when in culture with SN25ASP tumor supernatant (Figure 3G). This evidence concerns the gene NFKB1 and neoplasm.