Given a crucial involvement of NKG2D among others in PC (30–32), NKG2D in combination with 2B4 was selected to trigger effector functions of untouched resting NK cells that mediate host's intrinsic anti-tumor activity, on the basis of their high-level constitutive expression on resting NK cells, the capacity to trigger consistent and strong NK cell activation, and well-characterized cognate ligands (33, 34). The gene discussed is KLRK1; the disease is neoplasm.