To investigate the mechanism underlying the therapeutic effects of vibration stimuli on immobilization-induced soleus skeletal muscle atrophy, we first focused on the MGF, systemic variant of IGF-I, and muscle stem cells (Goldspink, 1999; Kandalla et al., 2011; Brooks and Myburgh, 2014; Gnimassou et al., 2017; Fukada, 2018). Here, IGF1 is linked to Skeletal muscle atrophy.