Furthermore, AM6545 treatment in WD mice that received oral gavage of CO increased levels of CCK-8 to those comparable to SD mice under the same conditions (Figure 3B; CO + WD + AM = 0.7 ± 0.1 ng per ml; p < 0.01 CO + WD versus CO + WD + AM, n = 6). This evidence concerns the gene CCK and Wilson disease.