Studies in Tg2576 and TgAPParc AD mice brains indicate the presence of S100A8 inclusions distinct from corpora amylacea, that are formed independently of Aβ plaques (Lodeiro et al., 2017), a feature which is likely tied to the self-assembly propensity of the S100 family members (Fritz et al., 2010; Carvalho et al., 2013a, 2013b). The gene discussed is S100A8; the disease is Alzheimer disease.