In this study, allele and genotype frequency distributions of TLR4 A896G (rs4986790), TLR4 C1196T (rs4986791), CD14 C-260T (rs2569190), RANKL (rs2277438), and OPG C163T (rs3102735) polymorphisms were analyzed in a total of 203 patients with periodontitis and 213 subjects without the disease. Here, TLR4 is linked to periodontitis.