Thus, the aim of this study was to evaluate the influence of the polymorphisms in TLR4 (rs4986790 and rs4986791), CD14 (rs2569190), RANKL (TNFSF11, rs2277438), and OPG (TNFSF11B, rs3102735) in the development of periodontitis. This evidence concerns the gene TLR4 and periodontitis.