2018b), we further observed the detoxification mechanism of LGT by analyses of Nrf2 protein and mRNA expression in liver and kidney of tumour mice. In this study, processing with medicinal herbs (JYH, BS, JQC, GC and LD) promoted Nrf2 nuclear accumulation in LGT-exposed tumour mice, evidenced by significantly upregulated Nrf2 protein levels, and mRNA levels of Nrf2 and its downstream target gene HO-1, suggesting that Nrf2 activation in liver could probably participate in the above medicinal processed-herb detoxification mechanism of LGT. The gene discussed is NFE2L2; the disease is neoplasm.