To this end, under the guidance of TCM theory, we conducted research on the detoxification mechanisms of LGT by processing with medicinal herbs with sweet properties (JYH, BS, JQC, GC and LD) and confirmed that processing with these herbs can all exhibit detoxification effects on LGT-induced hepatotoxicity and/or nephrotoxicity in S180 tumour-bearing mice and the mechanisms probably involved, at least in part, the Nrf2 antioxidant and anti-inflammatory processes. This evidence concerns the gene NFE2L2 and neoplasm.