TARDBP and mild neurocognitive disorder: ER stress has been strongly implicated in the pathogenesis of MND, and our study is among the first to show that ER stress can induce cytoplasmic accumulation of endogenous TDP-43, a major pathological hallmark of MND, although this has been shown using thapsigargin, which also induces ER stress [62, 63] This process is partially blocked by pharmacological inhibition of CK1, suggesting a key role for CK1.