While the specific pathological drivers of sporadic MND are largely uncharacterized, TDP-43 inclusions are somewhat reminiscent of stress granules (SGs) [31]—many cellular stresses have been shown to cause formation of SGs, which stain positive for T-intracellular antigen-1 cytotoxic granule-associated RNA binding protein-like 1 (TIAR) and Ras GTPase-activating protein-binding protein 1 (G3BP1) [32, 33]. Here, TARDBP is linked to mild neurocognitive disorder.