GDF-15 and NT-proBNP predicted CLT in unadjusted model (Supplementary Table S2), after adjustment for age, sex, BMI and fibrinogen (Supplementary Table 3) as well as after additional adjustment for coronary artery disease, heart failure/left ventricular dysfunction, GFR, antiplasmin, PAI-1, TAFI, CRP, cTnI-hs (Table 3). The gene discussed is SERPINE1; the disease is heart failure.