INS and diabetes mellitus: However, patients with diabetes mellitus, those using oral hypoglycemic drug or insulin did not differ from the remainder with regards to GDF-15 level (1491.0 [1075.0–1861.0] vs. 1727.0 [1073.3–2452.5] pg/mL, P = 0.30; 1526.0 [1042.0–1867.5] vs. 1705.0 [1094.0–2449.0] pg/mL, P = 0.49 and 1415.0 [940.8–2586.5] vs. 1684.0 [1129.3–2425.0] pg/mL, P = 0.61, respectively).