TYK2 and malignant peripheral nerve sheath tumor: The polycomb repressive complex 2 (PRC2)/polycomb repressive complex 2 subunit (SUZ12) has recently been shown to play an important role in MPNST pathogenesis.20, 21 Given that PRC2 loss occurs in 60%‐70% of MPNSTs and affects transcriptional regulation, we sought to determine whether there was a correlation between PRC2 loss and TYK2 expression, which could suggest a link between these events.