In our series, BCL6 was involved in localized mutational processes in M-CLL and MM reflecting their GC exposure, as expected; conversely, U-CLLs did not show any evidence of this process, confirming the GC-independent pathogenesis and suggesting the existence of a GC-unrelated AID activity in this group of patients. This evidence concerns the gene AICDA and B-cell chronic lymphocytic leukemia.