Furthermore, we showed how a comprehensive and detailed mutational signature analysis can provide relevant biological insights within different and well characterized cancer types, such as the c-AID activity among UM-IGHV, the absence of BRCA1/BRCA2-mediated HRD in a MM cohort and two mutational processes in AML, one related to platinum and one less characterized related to stem and progenitor bone marrow cells31,38,60–62. The gene discussed is BRCA1; the disease is acute myeloid leukemia.