Furthermore, we showed how a comprehensive and detailed mutational signature analysis can provide relevant biological insights within different and well characterized cancer types, such as the c-AID activity among UM-IGHV, the absence of BRCA1/BRCA2-mediated HRD in a MM cohort and two mutational processes in AML, one related to platinum and one less characterized related to stem and progenitor bone marrow cells31,38,60–62. This evidence concerns the gene BRCA2 and cancer.