This is especially true when it comes to assignment of flat signatures: our original analysis demonstrates that the previously identified presence of BRCA1/BRCA2-like HRD in an MM cohort is likely to be a false-positive call of fitting algorithms32, but this can only be demonstrated knowing the actual genomic consequences of BRCA deficiency in cancers and comparing them to what is seen in MM. The gene discussed is BRCA2; the disease is cancer.