NME1 and infection: Overexpression of AWD did not further inhibit ISC proliferation after recovery from Ecc15 challenge (Supplementary Fig. 6b), but knockdown of AWD prevented re-establishment of ISC quiescence, resulting in ISC over-proliferation at 24 h post Ecc15 infection (Fig. 6a), similar to Tkv or MAD loss of function conditions (Supplementary Fig. 6a).