We previously showed that the stimulation of A2AR is able to recover the abnormal phenotype of genetic NPC models such as fibroblasts from NPC1 patients15 and neuroblastoma SH-SY5Y and oligodendroglial MO3.13 cell lines transiently transfected with NPC1 siRNA16. Here, ADORA2A is linked to nasopharyngeal carcinoma.