ADORA2A and neuroblastoma: In particular, we demonstrated that A2AR stimulation restores calcium homeostasis, mitochondrial membrane potential (mMP) and cholesterol accumulation in fibroblasts from NPC1 patients and in human neuronal and oligodendroglial NPC1 cell lines (i.e. neuroblastoma SH-SY5Y and oligodendroglial MO3.13) transiently transfected with NPC1 small interfering RNA15,16.