For the main factors including BPTF, BUD31, CACNG1, RUNX1, GRK1, PTPRS, PRPF4B, and PBX1, most of these genetic alterations in breast cancer are dominated by amplifications (Fig. 5c), suggesting that enhanced expression levels of these candidates might be involved in breast cancer initiation or progression. Here, GRK1 is linked to breast carcinoma.