Furthermore, there was no significant difference in IFI16 mRNA levels between osteopenia and osteoporosis patients who were also suffering from chronic inflammatory disorders and those that were not, either when all osteopenia/osteoporosis patients (Supplementary Fig. S3a) or only female osteopenia/osteoporosis patients over the age of 50 (Supplementary Fig. S3b) were included (all osteopenia and osteoporosis patients, 95% CI = −0.032 to 0.097, P = 0.318; female osteopenia and osteoporosis patients over the age of 50, 95% CI = −0.075 to 0.088, P = 0.876, Student’s t-test). Here, IFI16 is linked to osteoporosis.