TLR4 haplotype GCAG [p = 0.0035, OR = 0.44 (0.20–0.96)] was associated with the decreased risk whereas TLR9 haplotype GATC [p = 0.018, OR = 4.15 (1.16–14.80)] was associated with the increased risk of acquiring HPV 16 and 18 infection compared with controls. The gene discussed is TLR9; the disease is infection.