Considering the importance of chronic inflammation in carcinogenesis as well as the influence of TLR genes’ polymorphisms in inflammation and cancer susceptibility, the present study was designed to investigate the role of four TLR4 (rs4986790, rs10759931, rs11536889 and rs1927911) and equal number of TLR9 (rs187084, rs5743836, rs352140 and rs352139) SNPs in HPV infection and cervical cancer susceptibility. This evidence concerns the gene TLR9 and cervical cancer.