With regard to non-synonymous SNP rs4986790 (A896G; Asp299Gly) of TLR4, intriguingly, we found the heterozygous AG genotype (Asp/Gly) to be strongly linked to HPV 16/18 infection suggesting a queering effect of the amino acid change as no interaction of HPV capsid proteins with TLR4 is known yet. Here, TLR4 is linked to infection.