Although no significant difference was observed between smokers and non-smokers in regard to cancer gene mutations, likely due to small sample size, EGFR mutations appeared to be more frequent in non-smokers than smokers (11/28 versus 7/25, p = 0.283, Chi-Square test), while smokers showed higher incidence of TP53 mutations (5/25 versus 1/28, p = 0.073, χ2 test) and CDKN2A loss or mutations (6/25 versus 2/28, p = 0.092, χ2 test). This evidence concerns the gene CDKN2A and cancer.