STK11 and medical procedure: In addition, loss of chromosomal segments containing STK11 was detected in 10% of AAH, 20% of AIS, 35.7% of MIA and 38.5% of ADC lesions (p = 0.02558, χ2 test for trend in proportions), implying STK11 loss may be a later genomic event during initiation or progression of lung preneoplasia.