To prove that, methionine-choline-deficient (MCD) diet-induced nonalcoholic steatohepatitis (NASH) model and carbon tetrachloride (CCl4)-induced liver fibrosis, two classic experimental murine liver fibrosis models, were used to study the dynamic expression of RXFP1 and its primary endogenous ligand, mouse RLN1 (equivalent to human RLN2, the major stored and circulating form of the RLN family, hereinafter referred as RLN), in the liver at different stages of fibrosis including the healthy state, fibrosis progression, and resolution. This evidence concerns the gene RLN1 and Hepatic fibrosis.