COL1A1 and idiopathic pulmonary fibrosis: Finally, whole-mount staining followed by confocal imaging and 3D reconstruction of IPF-derived PCLS (cultured for 5 days in the presence or absence of nintedanib or pirfenidone) revealed a slight decrease in COL1A1 deposition without an evident change in the abundance of LipidTOX+ cells (Supplementary Fig. 6K–O).