Interestingly, the majority of UTUC (WCM, BCM-MDA) tumors (28/32, 87.5%) were T-cell depleted (Fig. 4a) with consistent downregulation of T-cell related (CD8A, CCL2, CCL3, CCL4, CXCL9, CXCL10)15 and IFNG signaling genes16 (Fig. 4a). Here, CCL2 is linked to blue cone monochromacy.