When we applied the MDACC classifier which divides UC into luminal, basal, and p53-like subtypes4, we found that 22/32 (68.7%) of UTUC tumors clustered with the luminal subtype (Supplementary Fig. 2 and Supplementary Table 2) versus only 47/128 (36.7%) of UCB2. Here, TP53 is linked to renal pelvis/ureter urothelial carcinoma.