Moreover, in malignant glioma cells, the ATM-Akt signaling pathway could mediate cell migration, as discovered by Golding et al. [43].There was also evidence that a specific inhibitor of ATM (KU55933) could effectively inhibit cell migration induced by sorafenib, a chemotherapeutic agent, in HCC cells [44]. This evidence concerns the gene ATM and malignant glioma.