MK-2206 improved predicted pCR rates compared to standard chemotherapy in several breast cancer signatures, defined mostly by HR− and HER2+ patients, with predicted pCR rates with and without MK-2206 being 64.1% and 35.7% in HR−/HER2+ and 46.7% and 26.1% in HR−/HER2− patients respectively. The gene discussed is ERBB2; the disease is breast cancer.