In this study of 52 AKT1 E17K–mutant patients treated with AZD5363, confirmed partial responses were observed among patients with HR+ breast and endometrial cancers (n = 4 and n = 2, respectively), as well as cervical cancer, triple-negative breast cancer, and lung adenocarcinoma (n = 1 each), with four additional unconfirmed partial responses. Here, AKT1 is linked to lung adenocarcinoma.