Among them, Bliesath and colleagues, by combining the CK2 inhibitor CX-4945, and the EGFR tyrosine kinase inhibitor erlotinib, observed a synergistic antitumor effect in non-small cell lung carcinoma and squamous cell carcinoma, in vitro and in vivo, and demonstrated that it was mediated by an enhanced attenuation of the PI3K/AKT/mTOR pathway [100]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.