MAP2K7 and small cell lung carcinoma: Very recently, a study in KRAS-active non–small cell lung cancer cells resistant to EGFR inhibitors reported that single treatment with a CK2 inhibitor was not sufficient to completely impair cell viability, and an informatic analysis revealed MEK as a possible second target to overcome resistance; indeed, CX-4945 in combination with the MEK inhibitor AZD6244 displayed synergistic effects [99].