CDC37 is another CK2 substrate critically important in TKI resistance: in imatinib-resistant gastrointestinal stromal tumors (GIST) cells with constitutively active c-KIT receptor tyrosine kinase, a mechanism has been described where CK2 has a role through the phosphorylation of CDC37, which in turn, in a positive loop, contributes in maintaining high levels of CK2 itself. The gene discussed is NTRK1; the disease is gastrointestinal stromal tumor.