For example, Osthole, showed to inhibit collagen I and III expressions in TGF-β1 treated mouse cardiac fibroblasts (CFs) by modulating Smad4 expression [38] and Bergapten was reported to deplete estrogen receptor in breast cancer cells in respond to TGF β 1 by regulating Smad4 expression [39]. The gene discussed is ESR1; the disease is breast cancer.