Interestingly, in patients with euthyroid Graves’ disease, ITA-PSV was shown to be correlated with serum VEGF level, known to be a marker of intra-thyroid angiogenesis, whereas neither serum F-T4 nor F-T3 was found to have a relationship [12], suggesting that ITA-PSV reflects thyroid hormone production in euthyroid Graves’ disease. This evidence concerns the gene VEGFA and Graves disease.