ARHGAP42 and cancer: It is notable that ARHGAP42, a Rho GTPase activating protein, was another key result of Xu et al. [56], finding a place both in their set of 50 hub genes correlated with the BCLC staging of HCC patients, and in the set of 13 hub genes correlated with overall survival of HCC patients.Most of the stage-IV specific genes show contra-regulation (i.e, no clear trend) across cancer stages, and only 15 of the 35 genes revealed a monotonic pattern of expression (highlighted in Table 8).