In addition, EC dysfunction due to the overproduction of oxLDLs leads to imbalanced activation of nitric oxide synthase (NOS,) expressed constitutively by ECs (eNOS), thereby facilitating the activation of the inducible isoform of this enzyme (iNOS), which, in turn, enhances inflammatory processes within the vascular wall and contributes to atherosclerosis progression [6,7,8]. Here, NOS3 is linked to atherosclerosis.