In a cohort of 114 DLBCL cases, Jardin et al. observed REL gains in 18% (21/114) of all samples with a distribution amongst the GCB and ABC cluster of 6/64 (9%) and 10/27 (37%), respectively, while the remaining 5/23 (22%) samples were not classified. This evidence concerns the gene REL and diffuse large B-cell lymphoma.