Remarkably, two alternative versions of the REL transcript were identified in human B cell lymphoma: First, a REL transcript containing an exonized Alu element between exon 8 and 9 that could encode a protein of 619 amino acids [20], second, a lymphoma-specific splice variant of human c-Rel lacking the entire exon 9 (amino acids 308–330) with a higher in vitro transactivation activity [15]. The gene discussed is REL; the disease is B-cell non-Hodgkin lymphoma.