We found that a specific haplotype of H19 (CTG) was significantly associated with increased susceptibility to HCC (OR, 1.237; 95% CI, 1.015–1.507; p = 0.035; AOR, 1.240; 95% CI, 1.008–1.526; p = 0.042), further suggesting a genetic predisposition of H19 to liver cancer. The gene discussed is H19; the disease is hepatocellular carcinoma.