These results suggest that the upregulation of VEGFA, VEGFC, and VEGFD in MCF7-miR526b and MCF7-miR655 results in the production and release of these ligands into the tumour microenvironment, which may feed into an autocrine loop on breast cancer cells to activate VEGFR1 and VEGFR2 expression. The gene discussed is VEGFD; the disease is breast cancer.