TAMs produce growth and survival factors for tumor cells (e.g., EGF, fibroblast growth factor [FGF], IL-6, and IL-8) and angiogenic factors (EGF, FGF, vascular endothelial growth factor [VEGF], PDGF, TGF-β, and CXC chemokines) and suppress the T-cell dependent antitumor immunity [73]. This evidence concerns the gene VEGFA and neoplasm.