Noticeably, both PD901 and MLN0128 single treatments as well as PD901/MLN0128 combination exhibited superior therapeutic efficacy than sorafenib on AKT/c-MET mouse lesions, indicating that the combination of PD901 with MLN0128 might be an effective novel therapy for HCC subsets displaying high expression of c-MET and/or AKT/mTOR and Ras/MEK/MAPK pathways. The gene discussed is AKT1; the disease is hepatocellular carcinoma.