MTOR and hepatocellular carcinoma: At the molecular level, the levels of mTORC2 target phosphorylated/activated p-AKTS473, the mTORC1 target phosphorylated/activated p-RPS6 as well as phosphorylated/activated p-mTOR were strikingly reduced following MLN0128 administration in all HCC cell lines tested, whereas inconsistent results were detected when assessing the levels of phosphorylated PI3K (Figure 4).