This study extends the analysis of NR1, NR2A, and NR2B expressions with nNOS, eNOS, and iNOS activities in the cortex of young and old rats exposed to acute or chronic SD, to elucidate their changes related with aging and sleep impairments, with implications for age-related cognitive decline and pathobiology of AD. The gene discussed is GRIN2A; the disease is Alzheimer disease.