CD274 and non-small cell lung carcinoma: In 299 patients with advanced NSCLC and a high TMB (i.e., ≥10 mutations per megabase), significantly longer PFS was demonstrated in the treatment with nivolumab plus ipilimumab than that with chemotherapy, irrespective of the expression of PD-L1 (one-year PFS rate: 42.6% vs. 13.2%, respectively) [24].