In a larger study including 100 patients (i.e., 60 patients with advanced NSCLC and 40 patients with RCC) who had received anti-PD-1 immunotherapy, metagenomics of patient stool samples at diagnosis revealed correlations between clinical responses to ICIs and the relative abundance of Akkermansia muciniphila [55]. Here, PDCD1 is linked to renal cell adenocarcinoma.