Furthermore, recent studies demonstrated a cancer-prone stem cell niche at the hilum of the OSE in mice, characterized by cells expressing numerous stemness markers (ALDH1, LGR5, LEF1, CD133, CK6B) [14]; five stem cell markers (NANOG, SFRP1, LHX9, ALDH1A1, and ALDH1A2) were detected in both OSE and FTE [15]. The gene discussed is ALDH1A1; the disease is cancer.