These results are consistent with previous reports in AQP3-null mice, breast cancer, and sarcoma cells [18,29,30], and indicate that AQP3 and AQP5 play a role in the regulation of cell migration in pancreatic cancer cells, representing a promising target for the treatment of human pancreatic adenocarcinoma. This evidence concerns the gene AQP5 and pancreatic adenocarcinoma.