NF1 and Cowden disease: Patients with polypoid ganglioneuroma are not associated with NF1, MEN2b or other genetic syndromes.[10] The second type, ganglioneuromatous polyposis is characterized by numerous (more than 20) mucosal and/or submucosal polyps with a sessile or pedunculated form, and is predominately located in the colon and terminal ileum.[11] Ganglioneuromatous polyposis can be isolated or associated with one of the following syndromes: MEN2b, NF1, Cowden disease, non-familial colic polyposis or juvenile polyposis.