ECM-receptor interaction was a chief contributor of cancer progression.[28] Cytochrome P450 levels showed significant differences between ESCC patients and healthy subjects and may contribute to the development of ESCC.[29] The genetic polymorphism RsaI/PstI in cytochrome P450 2E1 (CYP2E1) was a risk factor for EC. This evidence concerns the gene CYP2E1 and cancer.