REN and hypertensive disorder: In addition, from the view of proteinuria, VEGF inhibition-induced proteinuria is associated with endothelial cell damage and slit membrane dysfunction, which are also caused by changes in blood flow dynamics, including elevation of renal glomerular internal pressure due to HT and decreased VEGF expression in glomerular epithelial cells.[28] Considering these mechanisms, renin-angiotensin inhibitors and angiotensin-converting enzyme inhibitors may be effective for treating VEGF inhibition-induced hypertension and proteinuria.