The differential activity of Ras/MAPK pathways and the RTK activation are involved in this process.[15] Some research has indicated that the expression of CCDC26 upregulated in glioma tissues and cell lines, and CCDC26-siRNA inhibited glioma growth and metastasis.[22] Further studies are needed to clarify the physiological function of CCDC26 and the functional consequence of these variants in vivo. The gene discussed is CCDC26; the disease is glioma.