TRPC1 and renal carcinoma: In order to test these effects of AM237 on endogenous TRPC1:C4 channels, A498 renal carcinoma cells, which endogenously express TRPC1:C4 channels (Akbulut et al., 2015; Carson et al., 2015; Ludlow et al., 2017), were pretreated with various concentrations of AM237 before the addition of EA.