Working with Janice Nigro and others in our lab (Figure 1), we found that 17p allelic losses coupled with missense mutations in the remaining p53 allele occurred in many tumors of the brain, breast, lung, and mesenchyme, in addition to a larger cohort of colorectal cancers (Nigro et al., 1989; Baker et al., 1990). Here, TP53 is linked to colorectal cancer.