Using this framework, we found evidence to support causal relationships between levels of circulating IL-18 and IBD, as well as eczema/dermatitis, circulating soluble IL-6R and eczema/dermatitis and circulating IL-2Rα and MS, amongst others (Supplementary Material, Tables S3–4, S6–8). This evidence concerns the gene IL18 and myeloid sarcoma.