While interleukin (IL)-12, interferon (IFN)-y, tumor necrosis factor (TNF)-α and soluble IL-2 receptor (sIL-2s) are elevated in both recent onset as well as chronic and medicated psychosis patients, pro-inflammatory cytokines IL-1β, IL-6 and transforming growth factor (TGF)-β are elevated only in patients with recent onset psychosis and acute relapse and normalized after antipsychotic treatment [3]. The gene discussed is PSMB6; the disease is psychotic disorder.