ITGAM and colitis: The CD103+ CD11b- intestinal DCs which preferentially induce gut-homing Tregs were found to be decreased in the lamina propria of the colon during colitis in mice and humans concomitant with an increase in the percentage of CD11b+ DCs, which promote differentiation of proinflammatory effector Th cells [29, 30, 31, 32].